Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Sep 10;56(17):7803-7.
doi: 10.1021/jf800728m. Epub 2008 Aug 9.

Protective Effects of Bilberry (Vaccinium Myrtillus L.) Extract on Restraint Stress-Induced Liver Damage in Mice

Affiliations

Protective Effects of Bilberry (Vaccinium Myrtillus L.) Extract on Restraint Stress-Induced Liver Damage in Mice

Li Bao et al. J Agric Food Chem. .

Abstract

Our experiments showed that 18 h restraint stress could induce serious liver damage, with an increase in plasma alanine aminotransferase (ALT) level (107.68 +/- 3.19 U/L vs 18.08 +/- 1.46 U/L). Meanwhile, we observed increased malondialdehyde (MDA) levels and lowered oxygen radical absorbance capacity (ORAC) values in plasma and liver of restraint mice compared with starved mice. Bilberry extract (containing 42.04% anthocyanins) was oral administrated to mice at 50, 100, and 200 mg/(kg x day) for five days, which remarkably decreased plasma ALT level to 17.23 +/- 2.49 U/L at the dose of 200 mg/(kg x day) and thus alleviated stress-induced liver damage. In addition, bilberry extracts increased glutathione (GSH) and vitamin C levels and significantly decreased MDA and nitric oxide (NO) levels in the liver tissues. These results suggest that bilberry extract plays an important role in protecting against restraint stress-induced liver damage by both scavenging free radicals activity and lipid peroxidation inhibitory effect. This study showed the beneficial health effects of bilberry extract through its antioxidative action.

Similar articles

See all similar articles

Cited by 7 articles

See all "Cited by" articles

LinkOut - more resources

Feedback