The increasing sclerosis of the human lens with age and its relevance to accommodation and presbyopia

Graefes Arch Clin Exp Ophthalmol. 1991;229(3):294-6. doi: 10.1007/BF00167888.


By means of a fine conical probe and a miniature dynamometer, the resistance to penetration of different lens layers was measured. In clear human lenses the power of resistance of the lens nucleus increases with age, mostly due to the "hardening" of the nucleus. A distinct hardening of the nucleus as opposed to the cortex has been found to occur in lenses as young as 20 years of age. This "firmness" of the lens nucleus, occurring between the ages of 20 and 60 years, coincides with the decrease in accommodation range and the onset of presbyopia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Accommodation, Ocular*
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / pathology*
  • Aging / physiology
  • Female
  • Humans
  • Lens, Crystalline / pathology*
  • Male
  • Middle Aged
  • Presbyopia / pathology*
  • Presbyopia / physiopathology
  • Sclerosis