Concentrations of acute-phase proteins in dogs with steroid responsive meningitis-arteritis

J Vet Intern Med. Sep-Oct 2008;22(5):1149-56. doi: 10.1111/j.1939-1676.2008.0164.x. Epub 2008 Aug 6.

Abstract

Background: Measurement of concentrations of acute-phase proteins (APPs) is used as an aid in the diagnosis of a variety of diseases in animals.

Objective: To determine the concentration of APPs in dogs with steroid responsive meningitis-arteritis (SRMA) and other neurologic diseases.

Animals: One hundred and thirty-three dogs with neurologic diseases, 6 dogs with sepsis, and 8 healthy dogs were included in the study. Thirty-six dogs had SRMA (31 of which had monitoring), 14 dogs had other meningoencephalitides (ME), 32 had disk disease (IVDD/DLSS), 26 had tumors affecting the central nervous system (TCNS), and 25 had idiopathic epilepsy (IE).

Methods: Prospective, observational study: C-reactive protein (CRP), alpha(2)-macroglobulin (AMG), and albumin concentrations were determined in the serum or plasma. CRP was also measured in the cerebrospinal fluid.

Results: Serum CRP was significantly higher in dogs with SRMA (x=142 microg/mL+/-75) and sepsis (x=114 microg/mL+/-67) in comparison with dogs with other neurologic diseases (x=2.3-21 microg/mL; P< .001). There was no significant difference detected in AMG between groups. Serum albumin concentration was significantly lower (P< .01) in dogs with SRMA (x=3.2 g/dL+/-0.41) than in other groups (x=3.6-3.9 g/dL). Serum CRP concentration of SRMA dogs correlated with alkaline phosphatase levels (r=0.515, P= .003).

Conclusions and clinical importance: CRP concentrations in serum are useful in diagnosis of dogs with SRMA. Serum CRP could be used as a monitoring parameter in treatment management of these dogs.

MeSH terms

  • Acute-Phase Proteins / analysis
  • Acute-Phase Proteins / metabolism*
  • Adrenal Cortex Hormones / therapeutic use*
  • Animals
  • Arteritis / cerebrospinal fluid
  • Arteritis / drug therapy
  • Arteritis / metabolism
  • Arteritis / veterinary*
  • Central Nervous System / immunology
  • Cerebrospinal Fluid / chemistry
  • Dog Diseases / blood*
  • Dog Diseases / immunology
  • Dogs
  • Female
  • Male
  • Meninges / blood supply
  • Meningitis / cerebrospinal fluid
  • Meningitis / drug therapy
  • Meningitis / metabolism
  • Meningitis / veterinary*

Substances

  • Acute-Phase Proteins
  • Adrenal Cortex Hormones