Beyond genetics: surprising determinants of cell fate in antitumor drugs

Cancer Cell. 2008 Aug 12;14(2):103-5. doi: 10.1016/j.ccr.2008.07.010.


In this issue of Cancer Cell, Gascoigne and Taylor (2008) report their findings of following 10,000 single cells incubated with three classes of antimitotic drugs, including paclitaxel (taxol). This extensive analysis reveals a previously unappreciated complexity in response to such drugs and demonstrates that it is more than genetics that determines cell life or death.

Publication types

  • Comment

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Cell Death / drug effects
  • Cell Lineage / drug effects*
  • Chromosomal Instability / drug effects
  • Genetics*
  • Humans
  • Neoplasms / enzymology
  • Neoplasms / pathology
  • Spindle Apparatus / drug effects
  • Spindle Apparatus / metabolism


  • Antineoplastic Agents