Physiochemical drug properties associated with in vivo toxicological outcomes

Bioorg Med Chem Lett. 2008 Sep 1;18(17):4872-5. doi: 10.1016/j.bmcl.2008.07.071. Epub 2008 Jul 24.


Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Dogs
  • Drug Evaluation, Preclinical
  • Drug-Related Side Effects and Adverse Reactions*
  • Female
  • Humans
  • Male
  • Pharmaceutical Preparations / chemistry*
  • Rats
  • Structure-Activity Relationship*


  • Pharmaceutical Preparations