Expression of forkhead transcription factors in human granulosa cells

Fertil Steril. 2009 Apr;91(4 Suppl):1392-4. doi: 10.1016/j.fertnstert.2008.04.054. Epub 2008 Aug 9.

Abstract

Members of the forkhead box O1 (FOXO) family of transcription factors are expressed in granulosa cells during various stages of follicle development, and evidence from rodent and other model systems suggests that they may be involved in regulating follicular activation and oocyte maturation. In this report, we show that FOXO1, FOXO3, and FOXO4 are expressed in human luteinized mural granulosa cells, which may suggest that these transcription factors are also involved in human folliculogenesis and luteinization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle Proteins
  • Female
  • Fertilization in Vitro
  • Forkhead Box Protein O1
  • Forkhead Box Protein O3
  • Forkhead Transcription Factors / metabolism*
  • Granulosa Cells / cytology
  • Granulosa Cells / metabolism*
  • Humans
  • Luteinization / physiology
  • Ovulation / physiology
  • Transcription Factors / metabolism*

Substances

  • Cell Cycle Proteins
  • FOXO1 protein, human
  • FOXO3 protein, human
  • FOXO4 protein, human
  • Forkhead Box Protein O1
  • Forkhead Box Protein O3
  • Forkhead Transcription Factors
  • Transcription Factors