The role of IL-10 in preventing food-induced anaphylaxis

Expert Opin Biol Ther. 2008 Sep;8(9):1309-17. doi: 10.1517/14712598.8.9.1309.


Background: Food allergy is a common condition resulting in a much impaired quality of life. So far, no clearly effective preventive and therapeutic strategies have been established. However, several options have been tested with promising results.

Objective: This review examines the potential of various strategies involving an IL-10-mediated effect for tolerance induction to food antigens, mostly for preventing food allergy.

Methods: In addition to a review of the literature, we describe and comment on experiments involving a Lactoccocus lactis strain transfected to secrete murine IL-10 directly into the gut.

Results/conclusion: This strain was efficient at preventing subsequent sensitization with a common food allergen. There appears to be a potential for such strategies for the prevention of human food allergy but further investigations will be needed to explore them.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphylaxis / physiopathology
  • Anaphylaxis / prevention & control*
  • Animals
  • Food Hypersensitivity / physiopathology
  • Food Hypersensitivity / prevention & control*
  • Humans
  • Interleukin-10 / biosynthesis
  • Interleukin-10 / therapeutic use*
  • Intestinal Mucosa / metabolism
  • Intestines / immunology
  • Intestines / microbiology
  • Intestines / physiopathology
  • Mice
  • Recombinant Proteins / therapeutic use


  • Recombinant Proteins
  • Interleukin-10