Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer

Cancer Lett. 2008 Dec 8;272(1):32-9. doi: 10.1016/j.canlet.2008.06.022. Epub 2008 Aug 9.


p21 and p27, members of the kinase inhibitor protein (KIP) family, bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell cycle arrest. The purpose of our study was to identify whether the p21 (C-to-A), and p27 (T-to-G) polymorphisms were associated with age at diagnosis of pancreatic cancer, either independently or jointly. Two hundred and five patients with a diagnosis of pancreatic cancer were genotyped for the p21 and p27 polymorphisms. We found patients with the p21 variant genotype (CA/AA) had an earlier age at diagnosis than those with the wild-type genotype (CC) (log-rank, P=0.001; HR=1.89; 95%CI, 1.28-2.78). The p21 and p27 polymorphisms combined had a joint effect on age-associated risk for early diagnosis of pancreatic cancer (log-rank, P=0.004; HR=2.91; 95%CI, 1.49-5.67). Our findings suggest that the p21 polymorphism independently and p21 and p27 polymorphisms jointly contribute to a significantly earlier age at diagnosis of pancreatic cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / genetics*
  • Age of Onset
  • Aged
  • Cyclin-Dependent Kinase Inhibitor p21 / genetics*
  • DNA Primers
  • Female
  • Genetic Variation
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Polymorphism, Single Nucleotide*
  • Proliferating Cell Nuclear Antigen / genetics*
  • Proportional Hazards Models
  • Proteasome Endopeptidase Complex / genetics
  • Racial Groups / genetics


  • Cyclin-Dependent Kinase Inhibitor p21
  • DNA Primers
  • PSMD9 protein, human
  • Proliferating Cell Nuclear Antigen
  • p27 antigen
  • Proteasome Endopeptidase Complex