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Case Reports
. 2008 Oct;88(3):291-293.
doi: 10.1007/s12185-008-0152-x. Epub 2008 Aug 12.

Hepatic Veno-Occlusive Disease After Tandem Autologous Stem Cell Transplantation Conditioned by Melphalan

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Case Reports

Hepatic Veno-Occlusive Disease After Tandem Autologous Stem Cell Transplantation Conditioned by Melphalan

Sana Intidhar Labidi et al. Int J Hematol. .

Abstract

We report the case of a 58-year-old man with multiple myeloma stage III A who received tandem autologous stem cell transplantation after induction by two courses of VAD and three cycles of bortezomib-dexamethasone, due to progression under chemotherapy. The second transplantation was complicated by severe hepatic veno-occlusive disease (HVOD). The patient received defibrotide with total recovery. The occurence of HVOD after conditioning by melphalan is uncommon and the role of bortezomib was questioned.

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