Paraneoplastic pemphigus regression after thymoma resection

World J Surg Oncol. 2008 Aug 12:6:83. doi: 10.1186/1477-7819-6-83.


Background: Among human neoplasms thymomas are associated with highest frequency with paraneoplastic autoimmune diseases.

Case presentation: A case of a 42-year-old woman with paraneoplastic pemphigus as the first manifestation of thymoma is reported. Transsternal complete thymoma resection achieved pemphigus regression. The clinical correlations between pemphigus and thymoma are presented.

Conclusion: Our case report provides further evidence for the important role of autoantibodies in the pathogenesis of paraneoplastic skin diseases in thymoma patients. It also documents the improvement of the associated pemphigus after radical treatment of the thymoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Paraneoplastic Syndromes / physiopathology*
  • Pemphigus / physiopathology*
  • Thymoma / pathology
  • Thymoma / surgery*
  • Thymus Neoplasms / pathology
  • Thymus Neoplasms / surgery*