Blueberry muffin baby: a pictoral differential diagnosis

Dermatol Online J. 2008 Feb 28;14(2):8.

Abstract

The term blueberry muffin baby was initially coined by pediatricians to describe cutaneous manifestations observed in newborns infected with rubella during the American epidemic of the 1960s. These children had generalized hemorrhagic purpuric eruptions that on histopathology showed dermal erythropoiesis. Since then, congenital infections comprising the TORCH syndrome (toxoplasmosis, other, rubella, cytomegalovirus, herpes) and hematologic dyscrasias have classically been associated with blueberry muffin-like lesion.

Publication types

  • Review

MeSH terms

  • Cytomegalovirus Infections / complications*
  • Cytomegalovirus Infections / congenital
  • Cytomegalovirus Infections / diagnosis
  • Cytomegalovirus Infections / physiopathology
  • Diagnosis, Differential
  • Hematologic Diseases / complications*
  • Hematologic Diseases / physiopathology
  • Hematopoiesis, Extramedullary*
  • Histiocytosis, Langerhans-Cell / diagnosis
  • Humans
  • Infant
  • Infant, Newborn
  • Leukemic Infiltration / diagnosis
  • Neuroblastoma / diagnosis
  • Purpura / diagnosis*
  • Purpura / etiology
  • Rubella Syndrome, Congenital / complications*
  • Rubella Syndrome, Congenital / diagnosis
  • Rubella Syndrome, Congenital / physiopathology
  • Sarcoma, Myeloid / diagnosis
  • Skin / pathology
  • Skin Diseases / diagnosis*
  • Skin Diseases / etiology
  • Syndrome