Recent advances in refractory coeliac disease: a review

Histopathology. 2009 Jun;54(7):783-95. doi: 10.1111/j.1365-2559.2008.03112.x. Epub 2009 Aug 12.


Coeliac disease (CD) is an immune-mediated disease of the small intestine caused by intolerance to gluten. Removal of gluten from the diet results in a return to normal health for the majority of patients. A significant proportion of patients do not respond to a gluten-free diet and are considered to be suffering from refractory coeliac disease (RCD). Two types of RCD are now recognized: type 1 RCD is characterized by a polyclonal population of intraepithelial lymphocytes (IELs) with a normal immunophenotype, and type 2 RCD shows monoclonal IELs with an aberrant immunoprofile. Patients with RCD have a high risk of complications such as ulcerative jejunitis (UJ) and enteropathy-type T-cell lymphoma (ETTL). RCD2 may represent an early stage in the development of overt lymphoma. The diagnosis of RCD, therefore, has important implications, but remains a challenging area. In this paper we review the latest developments in RCD, including the diagnostic approach and a discussion of the key clinical, histological, immunohistochemical and molecular features of RCD and its complications.

Publication types

  • Review

MeSH terms

  • Celiac Disease / complications
  • Celiac Disease / diagnosis*
  • Celiac Disease / immunology
  • Celiac Disease / therapy
  • Diet, Gluten-Free
  • Enteritis / etiology
  • Gastrointestinal Neoplasms / etiology
  • Humans
  • Jejunal Diseases / etiology
  • Lymphoma, Non-Hodgkin / etiology
  • Lymphoma, T-Cell / etiology