111/121 diplotype of Calpain-10 is associated with the risk of polycystic ovary syndrome in Korean women

Fertil Steril. 2009 Aug;92(2):830-3. doi: 10.1016/j.fertnstert.2008.06.023. Epub 2008 Aug 13.

Abstract

We investigated whether the CAPN-10 polymorphism UCSNP-43, -19, and -63 contribute, either individually or as haplotype/diplotype, to the susceptibility of polycystic ovary syndrome (PCOS) or related quantitative traits in Korean women. Our data showed that 111 haplotype and 111/121 and 111/111 diplotypes in the CAPN-10 gene were associated with a significantly increased risk of PCOS, and 112 haplotype and 121/121 and 112/122 diplotypes were associated with decreased risk of PCOS in the Korean population.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Calpain / genetics*
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Incidence
  • Korea / epidemiology
  • Polycystic Ovary Syndrome / epidemiology*
  • Polycystic Ovary Syndrome / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Assessment / methods
  • Risk Factors

Substances

  • Calpain
  • calpain 10