The HTLV-1 Tax interactome

Retrovirology. 2008 Aug 14;5:76. doi: 10.1186/1742-4690-5-76.

Abstract

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Gene Products, tax / chemistry
  • Gene Products, tax / genetics
  • Gene Products, tax / metabolism*
  • HTLV-I Infections / metabolism*
  • HTLV-I Infections / physiopathology
  • HTLV-I Infections / virology
  • Host-Pathogen Interactions*
  • Human T-lymphotropic virus 1 / chemistry
  • Human T-lymphotropic virus 1 / enzymology*
  • Human T-lymphotropic virus 1 / genetics
  • Humans
  • Nuclear Pore Complex Proteins / genetics
  • Nuclear Pore Complex Proteins / metabolism
  • Protein Binding
  • Protein Structure, Tertiary
  • Signal Transduction
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcriptional Activation

Substances

  • Cell Cycle Proteins
  • Gene Products, tax
  • Nuclear Pore Complex Proteins
  • Transcription Factors