Statins Limit Rickettsia Conorii Infection in Cells

Int J Antimicrob Agents. 2008 Oct;32(4):344-8. doi: 10.1016/j.ijantimicag.2008.04.027. Epub 2008 Aug 13.

Abstract

Recent data suggest that statins may have a beneficial effect during sepsis. In this study, we tested the effect of lovastatin and pravastatin on the cellular culture of Rickettsia conorii using a quantitative plaque assay model associated with an original image analysis algorithm. Statins added at the time of infection did not modify plaque formation, whereas pre-incubation with statins for 48h resulted in a significant 30-68% plaque reduction, depending on the tested compounds and doses. These preliminary findings raise the hypothesis that statins may prevent or moderate rickettsial disease in exposed people.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Anticholesteremic Agents / pharmacology*
  • Culture Media
  • Image Processing, Computer-Assisted
  • L Cells
  • Lovastatin / pharmacology*
  • Mice
  • Microbial Sensitivity Tests / methods
  • Pravastatin / pharmacology*
  • Rickettsia conorii / drug effects*
  • Rickettsia conorii / growth & development

Substances

  • Anticholesteremic Agents
  • Culture Media
  • Lovastatin
  • Pravastatin