A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes

Bioinformatics. 2008 Oct 15;24(20):2277-80. doi: 10.1093/bioinformatics/btn431. Epub 2008 Aug 14.


We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Conserved Sequence
  • Humans
  • Protein Folding
  • Protein Structure, Tertiary
  • RNA, Transfer / chemistry
  • RNA, Transfer / genetics
  • Ribonucleoproteins, Small Nuclear / chemistry*
  • Spliceosomes / metabolism*
  • Zinc Fingers*
  • tRNA Methyltransferases / chemistry*


  • Ribonucleoproteins, Small Nuclear
  • U11-U12 small nuclear ribonucleoprotein
  • RNA, Transfer
  • tRNA Methyltransferases