The effect of coenzyme Q10 on the pharmacokinetic parameters of theophylline

Arch Pharm Res. 2008 Jul;31(7):938-44. doi: 10.1007/s12272-001-1250-1. Epub 2008 Aug 14.

Abstract

Interaction of a drug with other drugs and dietary supplements is becoming an emerging issue for patients and health insurance authorities due to awareness of adverse drug event. In this study, we examined the effects of coenzyme Q10 (CoQ10), one of the most popular dietary supplements, on the pharmacokinetic parameters of theophylline in rats. The pharmacokinetic parameters of theophylline changed significantly when the drug was administered after five consecutive days of pretreatment with CoQ10. Time to reach maximum plasma concentration of theophylline delayed when the drug was administered after the pretreatment with CoQ10. Maximum plasma concentration and area under the curve of theophylline were about two-fold increased and other pharmacokinetic parameters such as half-life and volume of distribution were also changed significantly. Therefore, although CoQ10 is generally considered a safe dietary supplement, it appears that patients on theophylline therapy should use caution when they take CoQ10.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Bronchodilator Agents / blood
  • Bronchodilator Agents / pharmacokinetics*
  • Chromatography, High Pressure Liquid
  • Cytochrome P-450 CYP1A1 / metabolism
  • Cytochrome P-450 CYP1A2 / metabolism
  • Drug Interactions
  • Male
  • Protein Binding
  • Rats
  • Rats, Sprague-Dawley
  • Spectrophotometry, Ultraviolet
  • Theophylline / blood
  • Theophylline / pharmacokinetics*
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology

Substances

  • Antioxidants
  • Bronchodilator Agents
  • Ubiquinone
  • Theophylline
  • Cytochrome P-450 CYP1A1
  • Cytochrome P-450 CYP1A2
  • coenzyme Q10