Epilepsy surgery in tuberous sclerosis complex: early predictive elements and outcome

Childs Nerv Syst. 2008 Dec;24(12):1437-45. doi: 10.1007/s00381-008-0679-4. Epub 2008 Aug 14.


Aim: The aim of the study was to evaluate the surgical treatment of epilepsy and detection of possible early surgery predictive elements in patients with tuberous sclerosis complex (TSC).

Materials and methods: Forty-two TSC patients with epilepsy were selected and divided into two main groups: definite and fruste forms. Definite forms were divided into different groups: patients with pharmacologically controlled epilepsy, patients with pharmacoresistant epilepsy excluded from surgery after an extensive presurgical assessment, and patients with a pharmacoresistant epilepsy who underwent surgery. We compared the definite TSC groups to identify elements that predict surgical candidacy. Second, we compared all operated patients to assess surgical outcome.

Conclusion: We found several factors that could predict a surgical intervention even if identification of patients with refractory epilepsy who can benefit from surgery is an evolving process. Also, several positive factors for good surgical outcome were identified. Patients with the fruste form had excellent surgical outcome.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Epilepsy / complications
  • Epilepsy / drug therapy
  • Epilepsy / surgery*
  • Female
  • Humans
  • Male
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Tuberous Sclerosis / complications*
  • Young Adult