An overview of the etiology of otosclerosis

Eur Arch Otorhinolaryngol. 2009 Jan;266(1):25-35. doi: 10.1007/s00405-008-0790-x. Epub 2008 Aug 13.


Otosclerosis is the primary disease affecting the homeostasis of otic capsule and is among the most common causes of acquired hearing loss. Otosclerosis is considered as a multifactor disease, caused by both genetic and environmental factors. The aim of the present review is to summarize and analyze the bibliographic data, associated with the etiology of the disease. In some cases, the otosclerosis has an autosomal dominant mode of inheritance with incomplete penetrance. Genetic studies reveal the occurrence of at least nine chromosomal loci as candidate genes of the disease. The localized measles virus infection of the otic capsule has been postulated as a possible etiological theory. The role of hormonal factors, immune and bone-remodeling system in the etiopathogenesis of otosclerosis and the association of the disease with the disorders of the connective tissue are the issues of the present study. Despite the extensive research, many etiological factors and theories have been suggested and the process of development of the otosclerosis remains unclear.

Publication types

  • Review

MeSH terms

  • Bone Remodeling / genetics
  • Bone Remodeling / immunology
  • Chromosome Mapping
  • Collagen Diseases / complications
  • Endocrine System Diseases / complications*
  • Endocrine System Diseases / diagnosis
  • Female
  • Genetic Predisposition to Disease*
  • HLA-A Antigens / genetics
  • HLA-A Antigens / immunology
  • Humans
  • Male
  • Measles / complications*
  • Otosclerosis / etiology*
  • Otosclerosis / genetics
  • Otosclerosis / virology
  • Pregnancy
  • Prognosis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Risk Factors


  • HLA-A Antigens