Effects of hyperbaric oxygen therapy on wound healing after tracheal resection and end-to-end anastomoses in rats: results of early observations

Thorac Cardiovasc Surg. 2008 Sep;56(6):359-62. doi: 10.1055/s-2008-1038671.


Background: Proliferating scar tissue is an important problem after tracheal surgery. Hyperbaric oxygen (HBO) provides good support to the poorly perfused tissues. We aimed to evaluate the early effects of HBO therapy on tracheal healing after tracheal resection.

Methods: A total of 15 Wistar rats were divided into two groups and two tracheal rings of each rat were resected. A control group received no therapy while the other group was treated with HBO. At the end of the study or when a rat died, a histopathological examination was performed to assess neovascularization, necrosis and epithelization.

Results: HBO treatment caused better epithelization and inflammation scores compared to the control group. In the HBO group the intraluminal purulent exudates were limited (P=0.001). Healing of the damaged mucosal epithelium was better in the HBO group (P=0.031). In the HBO-treated group, neovascularization also started earlier than in the group without HBO.

Conclusion: Our short-term observation results demonstrate that HBO treatment increases tracheal healing and decreases the complication ratios. HBO may be preferred as a supportive treatment modality during the healing period after tracheal surgery.

MeSH terms

  • Anastomosis, Surgical / adverse effects
  • Animals
  • Cicatrix / etiology
  • Cicatrix / physiopathology
  • Cicatrix / prevention & control*
  • Disease Models, Animal
  • Female
  • Hyperbaric Oxygenation*
  • Neovascularization, Physiologic
  • Rats
  • Rats, Wistar
  • Trachea / pathology
  • Trachea / physiopathology
  • Trachea / surgery*
  • Tracheotomy / adverse effects*
  • Wound Healing*