A randomised controlled trial on the effectiveness of an advanced wound dressing used in Iran

J Wound Care. 2008 Jul;17(7):323-7. doi: 10.12968/jowc.2008.17.7.30525.

Abstract

Objective: To compare the wound healing rate and incidence of infection in wounds treated with either a bioactive dressing (containing hydrophilic mucopolysaccharide, chitosan) or conservative treatment (gauze).

Method: Eighty-five patients with diabetic foot ulcers, pressure ulcers or leg ulcers were randomised to receive either the bioactive study dressing (n=33 patients, 45 wounds) or the control dressing (n=52 patients, 53 wounds) for 21 days. Wound size, stage where appropriate and the presence of infection were recorded at each dressing change. Thirty-one of these 85 patients dropped out of the study during the three-month post-treatment follow-up, when wound size and grade were assessed on a monthly basis. Data were therefore analysed on 54 patients, of whom 32 (34 wounds) were in the treatment group and 22 (26 wounds) in the control group.

Results: In the control group, four pressure ulcers healed, but the remaining wounds all deteriorated and became infected, requiring antibiotics. In contrast, in the treatment group 29/34 wounds healed completely, and none became infected; the remaining five wounds healed during the follow-up period. The difference between the two groups in the number of wounds that healed was statistically significant (p<0.001), as was that for the number of healed pressure ulcers p<0.05.

Conclusion: Use of a moist bioactive wound dressing significantly increased the healing rate when compared with the traditional dressings used in the participating hospitals. This will in turn bring significant cost savings.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alginates / therapeutic use
  • Analysis of Variance
  • Bandages / economics
  • Bandages / standards*
  • Biocompatible Materials / economics
  • Biocompatible Materials / pharmacology
  • Biocompatible Materials / therapeutic use*
  • Chi-Square Distribution
  • Chitosan / economics
  • Chitosan / pharmacology
  • Chitosan / therapeutic use*
  • Clinical Nursing Research
  • Cost Savings
  • Diabetic Foot / pathology
  • Diabetic Foot / therapy*
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Glucuronic Acid / therapeutic use
  • Hexuronic Acids / therapeutic use
  • Humans
  • Iran
  • Leg Ulcer / pathology
  • Leg Ulcer / therapy*
  • Male
  • Middle Aged
  • Pressure Ulcer / pathology
  • Pressure Ulcer / therapy*
  • Severity of Illness Index
  • Skin Care / economics
  • Skin Care / methods
  • Skin Care / nursing
  • Treatment Outcome
  • Wound Healing

Substances

  • Alginates
  • Biocompatible Materials
  • Hexuronic Acids
  • Glucuronic Acid
  • Chitosan