Base-pairing models to account for the mutagenicity and specificity of the purine analog 2-amino-N6-hydroxyadenine

C Janion

doi:10.1016/0165-1161(91)90341-5

Base-pairing models to account for the mutagenicity and specificity of the purine analog 2-amino-N6-hydroxyadenine

Mutat Res. 1991 Aug;253(1):17-20. doi: 10.1016/0165-1161(91)90341-5.

Author

C Janion¹

Affiliation

¹ Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw.

PMID: 1870607
DOI: 10.1016/0165-1161(91)90341-5

Abstract

Potential base-pairing mechanisms of the purine analog, 2-amino-N6-hydroxyadenine (AHA), with the natural bases of DNA are presented. Base-pairing properties of this analog indicate that AHA may induce transitions and transversions of base pairs in DNA.

MeSH terms

Adenine / analogs & derivatives*
Adenine / chemistry
Adenine / toxicity
DNA Damage
Hydrogen Bonding
Mutagens*
Structure-Activity Relationship

Substances

Mutagens
2-amino-N(6)-hydroxyadenine
Adenine