Hypoxia Downregulates Ku70/80 Expression in Cervical Carcinoma Tumors

Radiother Oncol. 2008 Nov;89(2):222-6. doi: 10.1016/j.radonc.2008.07.018. Epub 2008 Aug 14.

Abstract

Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Nuclear / genetics*
  • DNA-Binding Proteins / genetics*
  • Down-Regulation
  • Female
  • Humans
  • Hypoxia / genetics*
  • Immunoenzyme Techniques
  • Ku Autoantigen
  • Middle Aged
  • Prospective Studies
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / radiotherapy

Substances

  • Antigens, Nuclear
  • DNA-Binding Proteins
  • Xrcc6 protein, human
  • Ku Autoantigen