Spin trapping experiments with different carbamoyl-substituted EMPO derivatives

Klaus Stolze; Natascha Rohr-Udilova; Andreas Hofinger; Thomas Rosenau

doi:10.1016/j.bmc.2008.07.057

Spin trapping experiments with different carbamoyl-substituted EMPO derivatives

Bioorg Med Chem. 2008 Sep 1;16(17):8082-9. doi: 10.1016/j.bmc.2008.07.057. Epub 2008 Jul 25.

Authors

Klaus Stolze¹, Natascha Rohr-Udilova, Andreas Hofinger, Thomas Rosenau

Affiliation

¹ Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinärplatz 1, A-1210 Vienna, Austria. Klaus.Stolze@vu-wien.ac.at

PMID: 18706818
DOI: 10.1016/j.bmc.2008.07.057

Abstract

The spin trapping behavior of five carbamoyl-substituted EMPO derivatives, 5-aminocarbonyl-5-methyl-pyrroline N-oxide (CAMPO (AMPO)), 5-aminocarbonyl-5-ethyl-pyrroline N-oxide (CAEPO), 5-aminocarbonyl-5-propyl-pyrroline N-oxide (CAPPO), 5-aminocarbonyl-5-n-butyl-pyrroline N-oxide (CABPO), and 5-aminocarbonyl-5-n-pentyl-pyrroline N-oxide (CAPtPO), toward different oxygen- and carbon-centered radicals is described, the stabilities of the superoxide adducts ranging from about 8 to 17min.

MeSH terms

Carbon / chemistry
Cyclic N-Oxides / chemistry*
Electron Spin Resonance Spectroscopy / instrumentation
Electron Spin Resonance Spectroscopy / methods
Free Radicals / chemistry
Kinetics
Magnetic Resonance Spectroscopy / instrumentation
Magnetic Resonance Spectroscopy / methods
Molecular Structure
Oxygen / chemistry
Spectrophotometry, Infrared / instrumentation
Spectrophotometry, Infrared / methods
Spectrophotometry, Ultraviolet / instrumentation
Spectrophotometry, Ultraviolet / methods
Spin Trapping / instrumentation
Spin Trapping / methods*
Stereoisomerism

Substances

5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide
Cyclic N-Oxides
Free Radicals
Carbon
Oxygen