Cardiovascular risk factors in the Japanese northeastern rural population

Int J Cardiol. 2009 Nov 12;137(3):226-35. doi: 10.1016/j.ijcard.2008.06.052. Epub 2008 Aug 15.


Background: People living in the northeastern part of Japan have high prevalences of hypertension and stroke. The current status of cardiovascular risk factors in them should be elucidated.

Methods: The survey was carried out from 2002 to 2004 in the northeastern part of the main island of Japan. A total of 26,472 Japanese men and women were enrolled (acceptance rate: 84.5%). Sex- and age-specific prevalences of cardiovascular risk factors were determined. Mean values of predictive markers (high-sensitivity C reactive protein (hsCRP), brain natriuretic peptide (BNP) and microalbuminuria) were also determined in each group. Risk factor-related variables in non-hypertensive subjects and hypertensive subjects were compared.

Results: Proportions of subjects with hypertension, diabetes and dyslipidemia were 46.0%, 7.6%, and 30.3%, respectively, in males and 38.6%, 4.0%, and 38.5%, respectively, in females. Mean values of hsCRP and BNP were 1.41 mg/L and 26.5 pg/mL, respectively, in males and 1.01 mg/L and 23.7 pg/mL, respectively, in females. Proportions of male and female subjects with microalbuminuria were 22.0% and 23.4%, respectively. These markers become higher with advance of age. Prevalence of atrial fibrillation was 1.56%, and it increased with advance of age in both men and women. High prevalences of cardiovascular risk factors in this area were found. Hypertensive subjects who did not take anti-hypertension medication accounted for about 20% of total subjects and their blood pressure remained poorly controlled.

Conclusion: Attention should be given to cardiovascular risk factors in the Japanese northeastern rural population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / analysis
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / etiology*
  • Diabetes Mellitus / epidemiology
  • Dyslipidemias / complications
  • Dyslipidemias / epidemiology
  • Female
  • Humans
  • Hypertension / complications
  • Hypertension / epidemiology
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prevalence
  • Risk Factors
  • Rural Population*
  • Surveys and Questionnaires


  • Biomarkers