SOCS regulation of the JAK/STAT signalling pathway

Semin Cell Dev Biol. 2008 Aug;19(4):414-22. doi: 10.1016/j.semcdb.2008.07.010. Epub 2008 Jul 30.


The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling. In this review we focus on the mechanics of SOCS action and the complexities of the mouse models that have underpinned our current understanding of SOCS biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cytokines / metabolism
  • Humans
  • Janus Kinases / metabolism*
  • Molecular Sequence Data
  • STAT Transcription Factors / metabolism*
  • Sequence Alignment
  • Signal Transduction / physiology*
  • Suppressor of Cytokine Signaling Proteins / genetics
  • Suppressor of Cytokine Signaling Proteins / metabolism*


  • Cytokines
  • STAT Transcription Factors
  • Suppressor of Cytokine Signaling Proteins
  • Janus Kinases