c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model

Mol Cancer Res. 2008 Aug;6(8):1289-92. doi: 10.1158/1541-7786.MCR-08-0036.


The oncogene c-Jun has been found to be up-regulated in a variety of cancers including osteosarcoma. DNA enzymes (DNAzymes) are oligonucleotides capable of specific catalysis of target mRNA. A c-Jun DNAzyme inhibited the growth and metastasis of osteosarcoma in an orthotopic spontaneously metastasizing model of the disease. c-Jun down-regulation-mediated apoptosis in osteosarcoma cells involved caspase-1, caspase-2, and caspase-8, but not the Fas/FasL pathway. Clinically, knockdown of c-Jun with DNAzymes may proffer an improved treatment outcome for these tumors originating in bone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Bone Neoplasms / pathology*
  • Cell Line, Tumor
  • DNA, Catalytic / pharmacology
  • Disease Models, Animal
  • Disease Progression
  • Down-Regulation / drug effects
  • Humans
  • Mice
  • Neoplasm Metastasis
  • Osteosarcoma / pathology*
  • Proto-Oncogene Proteins c-jun / metabolism*


  • DNA, Catalytic
  • Dz13 DNAzyme
  • Proto-Oncogene Proteins c-jun