Simultaneous MR/PET imaging of the human brain: feasibility study

Radiology. 2008 Sep;248(3):1028-35. doi: 10.1148/radiol.2483071927.


The purpose of this study was to apply a magnetic resonance (MR) imaging-compatible positron emission tomographic (PET) detector technology for simultaneous MR/PET imaging of the human brain and skull base. The PET detector ring consists of lutetium oxyorthosilicate (LSO) scintillation crystals in combination with avalanche photodiodes (APDs) mounted in a clinical 3-T MR imager with use of the birdcage transmit/receive head coil. Following phantom studies, two patients were simultaneously examined by using fluorine 18 fluorodeoxyglucose (FDG) PET and MR imaging and spectroscopy. MR/PET data enabled accurate coregistration of morphologic and multifunctional information. Simultaneous MR/PET imaging is feasible in humans, opening up new possibilities for the emerging field of molecular imaging.

Publication types

  • Evaluation Study

MeSH terms

  • Brain / diagnostic imaging*
  • Brain / pathology*
  • Feasibility Studies
  • Fluorodeoxyglucose F18*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Radiography
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18