SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

Nat Genet. 2008 Sep;40(9):1098-102. doi: 10.1038/ng.208.

Abstract

We conducted a genome-wide association study using 207,097 SNP markers in Japanese individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium voltage-gated channel, KQT-like subfamily, member 1) to be a strong candidate for conferring susceptibility to type 2 diabetes. We detected consistent association of a SNP in KCNQ1 (rs2283228) with the disease in several independent case-control studies (additive model P = 3.1 x 10(-12); OR = 1.26, 95% CI = 1.18-1.34). Several other SNPs in the same linkage disequilibrium (LD) block were strongly associated with type 2 diabetes (additive model: rs2237895, P = 7.3 x 10(-9); OR = 1.32, 95% CI = 1.20-1.45, rs2237897, P = 6.8 x 10(-13); OR = 1.41, 95% CI = 1.29-1.55). The association of these SNPs with type 2 diabetes was replicated in samples from Singaporean (additive model: rs2237895, P = 8.5 x 10(-3); OR = 1.14, rs2237897, P = 2.4 x 10(-4); OR = 1.22) and Danish populations (additive model: rs2237895, P = 3.7 x 10(-11); OR = 1.24, rs2237897, P = 1.2 x 10(-4); OR = 1.36).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian Continental Ancestry Group / genetics*
  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / genetics
  • European Continental Ancestry Group / genetics*
  • Gene Expression
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • KCNQ1 Potassium Channel / genetics*
  • Polymorphism, Single Nucleotide
  • Singapore

Substances

  • KCNQ1 Potassium Channel
  • KCNQ1 protein, human