How chemokines invite leukocytes to dance

Nat Immunol. 2008 Sep;9(9):953-9. doi: 10.1038/ni.f.207.

Abstract

A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here we summarize recent findings on the initial steps in chemokine receptor-induced signal transduction in leukocytes. In particular, we discuss the potential influences of the formation of oligomers of ligand and receptor and of coupling between chemokine signals and regulators of the cytoskeleton, such as small GTPases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemokines / immunology*
  • Chemokines / metabolism*
  • GTP Phosphohydrolases / metabolism
  • Humans
  • Leukocytes / immunology*
  • Lymphocyte Activation
  • Receptors, Chemokine / metabolism
  • Signal Transduction*

Substances

  • Chemokines
  • Receptors, Chemokine
  • GTP Phosphohydrolases