Computational diagnostics with gene expression profiles

Methods Mol Biol. 2008;453:281-96. doi: 10.1007/978-1-60327-429-6_15.


Gene expression profiling using micro-arrays is a modern approach for molecular diagnostics. In clinical micro-array studies, researchers aim to predict disease type, survival, or treatment response using gene expression profiles. In this process, they encounter a series of obstacles and pitfalls. This chapter reviews fundamental issues from machine learning and recommends a procedure for the computational aspects of a clinical micro-array study.

MeSH terms

  • Animals
  • Computational Biology / methods*
  • Databases, Genetic
  • Gene Expression Profiling / methods*
  • Humans
  • Molecular Diagnostic Techniques*
  • Oligonucleotide Array Sequence Analysis / methods*