Scintigraphic studies of inflammation in diffuse lung disease

Radiol Clin North Am. 1991 Sep;29(5):1095-114.

Abstract

67Ga lung scintigraphy is an established means to assess alveolar inflammation in a wide variety of diffuse lung diseases. It can be used to monitor the extent and activity of the alveolitis during the course of the disease and as a follow-up evaluation to therapy. Although the mechanism of 67Ga localization is not established firmly, the isotope appears to act as a tracer for disturbed protein and cellular fluxes within the interstitium and alveolar spaces. The radiolabeled aerosol study may also be applied to the study of these fluxes as a reflection of inflammation and injury. Although Tc-DTPA clearance studies are highly sensitive to lung injury, they may be too nonspecific to separate lung injury from other physiologic processes effectively.

Publication types

  • Review

MeSH terms

  • Gallium Radioisotopes
  • Humans
  • Inflammation
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / etiology
  • Lung Diseases / pathology
  • Lung Diseases / physiopathology
  • Pneumoconiosis / diagnostic imaging
  • Radiography
  • Radionuclide Imaging
  • Sarcoidosis / diagnostic imaging

Substances

  • Gallium Radioisotopes