PPF1 may suppress plant senescence via activating TFL1 in transgenic Arabidopsis plants

J Integr Plant Biol. 2008 Apr;50(4):475-83. doi: 10.1111/j.1744-7909.2008.00643.x.


Senescence, a sequence of biochemical and physiological events, constitutes the final stage of development in higher plants and is modulated by a variety of environmental factors and internal factors. PPF1 possesses an important biological function in plant development by controlling the Ca2+ storage capacity within chloroplasts. Here we show that the expression of PPF1 might play a pivotal role in negatively regulating plant senescence as revealed by the regulation of overexpression and suppression of PPF1 on plant development. Moreover, TFL1, a key regulator in the floral repression pathway, was screened out as one of the downstream targets for PPF1 in the senescence-signaling pathway. Investigation of the senescence-related phenotypes in PPF1(-) tfl1-1 and PPF1(+) tfl1-1 double mutants confirmed and further highlighted the relation of PPF1 with TFL1 in transgenic plants. The activation of TFL1 expression by PPF1 defines an important pathway possibly essential for the negative regulation of plant senescence in transgenic Arabidopsis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arabidopsis / cytology
  • Arabidopsis / genetics*
  • Arabidopsis / growth & development*
  • Arabidopsis Proteins / metabolism*
  • Calcium-Binding Proteins / metabolism*
  • Cell Differentiation
  • Chlorophyll / metabolism
  • DNA, Complementary / genetics
  • Flowers / genetics
  • Gene Expression Regulation, Plant
  • Malondialdehyde / metabolism
  • Mutation / genetics
  • Phenotype
  • Plants, Genetically Modified
  • Reverse Transcriptase Polymerase Chain Reaction
  • Time Factors


  • Arabidopsis Proteins
  • Calcium-Binding Proteins
  • DNA, Complementary
  • TFL1 protein, Arabidopsis
  • Chlorophyll
  • Malondialdehyde