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Randomized Controlled Trial
. 2008 Oct;10(5):405-12.
doi: 10.1089/dia.2007.0292.

Effects of Chromium Picolinate on Food Intake and Satiety

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Free PMC article
Randomized Controlled Trial

Effects of Chromium Picolinate on Food Intake and Satiety

Stephen D Anton et al. Diabetes Technol Ther. .
Free PMC article

Abstract

Background: Chromium picolinate (CrPic) has been shown to attenuate weight gain, but the mechanism underlying this effect is unknown.

Methods: We assessed the effect of CrPic in modulating food intake in healthy, overweight, adult women who reported craving carbohydrates (Study 1) and performed confirmatory studies in Sprague-Dawley rats (Study 2). Study 1 utilized a double-blind placebo-controlled design and randomly assigned 42 overweight adult women with carbohydrate cravings to receive 1,000 mg of CrPic or placebo for 8 weeks. Food intake at breakfast, lunch, and dinner was directly measured at baseline, week 1, and week 8. For Study 2, Sprague-Dawley rats were fasted for 24 h and subsequently injected intraperitoneally with 0, 1, 10, or 50 microg/kg CrPic. Subsequently, rats were implanted with an indwelling third ventricular cannula. Following recovery, 0, 0.4, 4, or 40 ng of CrPic was injected directly into the brain via the intracerebroventricular cannula, and spontaneous 24-h food intake was measured.

Results: Study 1 demonstrated that CrPic, as compared to placebo, reduced food intake (P<0.0001), hunger levels (P<0.05), and fat cravings (P<0.0001) and tended to decrease body weight (P=0.08). In study 2, intraperitoneal administration resulted in a subtle decrease in food intake at only the highest dose (P=0.03). However, when administered centrally, CrPic dose-dependently decreased food intake (P<0.05).

Conclusions: These data suggest CrPic has a role in food intake regulation, which may be mediated by a direct effect on the brain.

Figures

FIG. 1.
FIG. 1.
Illustration of the number of participants from recruitment to the end of the study.
FIG. 2.
FIG. 2.
Change in food intake over the entire day for participants assigned to receive CrPic (n = 21) versus placebo (n = 19).
FIG. 3.
FIG. 3.
Effect of intraperitoneal and intra-cerebroventricular CrPic injection on 24-h food intake in Sprague-Dawley rats. (A) 24-h fasted rats were injected intraperitoneally with increasing doses of CrPic, and 24-h food intake was assessed. (B) Rats implanted with an indwelling intracerebroventricular cannula were injected intracerebroventricularly with lower doses of CrPic, and 24-h food intake was assessed. *P < 0.05, **P < 0.01 versus vehicle (Veh).

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