Neurocognitive enhancement therapy with vocational services: work outcomes at two-year follow-up

Schizophr Res. 2008 Oct;105(1-3):18-29. doi: 10.1016/j.schres.2008.06.026. Epub 2008 Aug 19.


Neurocognitive enhancement therapy (NET) is a remediation program for the persistent and function-limiting cognitive impairments of schizophrenia. In a previous study in veterans, NET improved work therapy outcomes as well as executive function and working memory. The present study aimed to determine whether NET could enhance functional outcomes among schizophrenia and schizoaffective patients in a community mental health center receiving community-based vocational services.

Method: Patients (N=72) participated in a hybrid transitional and supported employment program (VOC) and were randomized to either NET+VOC or VOC only. NET+VOC included computer-based cognitive training, work feedback and a social information information-processing group. VOC only also included two weekly support groups. Active intervention was 12 months with 12 month follow-up. Follow-up rate was 100%.

Results: NET+VOC patients worked significantly more hours during the 12 month follow-up period, reached a significantly higher cumulative rate of competitive employment by the sixth quarter, and maintained significantly higher rates of employment.

Conclusion: NET training improved vocational outcomes, suggesting the value of combining cognitive remediation with other rehabilitation methods to enhance functional outcomes.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Cognition Disorders / diagnosis
  • Cognition Disorders / psychology
  • Cognition Disorders / rehabilitation
  • Cognitive Behavioral Therapy / methods*
  • Combined Modality Therapy
  • Employment
  • Employment, Supported*
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Neuropsychological Tests / statistics & numerical data
  • Occupational Therapy
  • Psychiatric Status Rating Scales
  • Psychotherapy, Group
  • Psychotic Disorders / psychology
  • Psychotic Disorders / rehabilitation
  • Rehabilitation, Vocational / methods*
  • Schizophrenia / diagnosis
  • Schizophrenia / rehabilitation*
  • Schizophrenia / therapy
  • Schizophrenic Psychology*
  • Treatment Outcome
  • Vocational Education