Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors

J Virol. 2008 Nov;82(21):10953-8. doi: 10.1128/JVI.01312-08. Epub 2008 Aug 20.


The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a common ancestor with the domestic cat (Felis catus) lentivirus (FIV(Fca)). Here we demonstrate that FIV(Ple)-E and FIV(Fca) share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIV(Ple)-E. The shared usage of CD134 and CXCR4 by FIV(Fca) and FIV(Ple)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cats / virology*
  • Cell Line
  • Genes, Reporter
  • Giant Cells / cytology
  • Giant Cells / virology
  • Immunodeficiency Virus, Feline / genetics
  • Immunodeficiency Virus, Feline / isolation & purification
  • Immunodeficiency Virus, Feline / physiology*
  • Lions / virology*
  • Luciferases / genetics
  • Luciferases / metabolism
  • Molecular Sequence Data
  • RNA, Viral / genetics
  • Receptors, CXCR4 / metabolism*
  • Receptors, OX40 / metabolism*
  • Receptors, Virus*
  • Sequence Analysis, DNA
  • Virus Internalization*


  • RNA, Viral
  • Receptors, CXCR4
  • Receptors, OX40
  • Receptors, Virus
  • Luciferases

Associated data

  • GENBANK/EU915482
  • GENBANK/EU915483
  • GENBANK/EU915484