This report summarizes 2008 West Nile virus (WNV) surveillance data reported to CDC through ArboNET as of 3 a.m. Mountain Daylight Time, August 19, 2008. A total of 28 states have reported 236 cases of human WNV illness to CDC. A total of 137 (58%) cases for which such data were available occurred in males; median age of patients was 48 years (range: 10 months-86 years). Dates of illness onset ranged from January 17 to August 14; two cases were fatal.