An asymptomatic 13 year old with a history of neuroblastoma treated with chemotherapy, radiation therapy, and autologous bone marrow transplant was found to have a cardiac mass on screening echocardiogram. Surgical resection and histologic examination revealed the mass was a myxoma. After resection the patient made a full recovery. This report reviews the features of myxoma and explores the potential relationship between chemotherapy, radiation, bone marrow transplant and myxoma.