Implementation of an insulin protocol using a multiplier-based calculation for determining infusion rates in critically ill patients

S D Med. 2008 Jul;61(7):247, 249-53.


Evaluation of a nurse-titrated insulin infusion method for hyperglycemia treatment was conducted on data from a 19-bed mixed medical-surgical intensive care unit (ICU) with results demonstrating that glucose management did not consistently meet target glucose goals. A multidisciplinary team was created to evaluate and implement a method of insulin infusion administration that would decrease titration subjectivity and improve glycemic management. Utilizing a Plan-Do-Study-Act (PDSA) cycle for trial implementation of a calculation-based method, data demonstrated a significant improvement in glycemic management when compared to the previous method of insulin administration.

Publication types

  • Clinical Trial

MeSH terms

  • Critical Illness*
  • Humans
  • Hyperglycemia / drug therapy*
  • Insulin / administration & dosage*
  • Insulin / therapeutic use
  • Insulin Infusion Systems*
  • Patient Care Team
  • Retrospective Studies
  • Titrimetry


  • Insulin