Evaluation of a nurse-titrated insulin infusion method for hyperglycemia treatment was conducted on data from a 19-bed mixed medical-surgical intensive care unit (ICU) with results demonstrating that glucose management did not consistently meet target glucose goals. A multidisciplinary team was created to evaluate and implement a method of insulin infusion administration that would decrease titration subjectivity and improve glycemic management. Utilizing a Plan-Do-Study-Act (PDSA) cycle for trial implementation of a calculation-based method, data demonstrated a significant improvement in glycemic management when compared to the previous method of insulin administration.