The effects of high frequency, low intensity ultrasound therapy on parotid flow rates

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Nov;106(5):e16-9. doi: 10.1016/j.tripleo.2008.06.013. Epub 2008 Aug 20.


Objectives: Saliva plays a critical role in maintaining oral health and comfort. Development of a single device capable of simulating salivary flow with no taste or adverse side effects is desirable.

Study design: This clinical investigation on 23 healthy volunteers with no dry mouth complaints evaluated the effectiveness of ultrasonic therapy in mechanical stimulation of the parotid gland to increase saliva flow. Stimulated and unstimulated parotid saliva was collected. Differences in mean salivary flow rates and affects of age and ethnicity were measured.

Results: The mean difference between stimulated and unstimulated saliva flow rates was 0.009 mL/min +/- SD = 0.042, t (df = 22) = 1.27 with P = .31. There were no significant differences of age (P = .26), gender (P = .38), or race/ethnicity (P = .58) for the difference of stimulated and unstimulated conditions.

Conclusions: Results indicate that high-frequency low-intensity ultrasound therapy is not effective in stimulating salivary flow rates.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parotid Gland / physiology*
  • Physical Stimulation / methods
  • Saliva / metabolism*
  • Secretory Rate
  • Ultrasonic Therapy*
  • Young Adult