Overexpression of thymic stromal lymphopoietin in allergic rhinitis

Acta Otolaryngol. 2009 Mar;129(3):297-301. doi: 10.1080/00016480802225884.

Abstract

Conclusion: Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR.

Objective: To evaluate the possible role of TSLP in the pathogenesis of AR.

Patients and methods: We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link of TSLP and interleukin-4 (IL-4). Expression of TSLP was detected by immunohistochemical analysis and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and concentrations of TSLP and IL-4 were measured by enzyme-linked immunosorbent assay (ELISA).

Results: TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P<0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P<0.05).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Cytokines / genetics
  • Cytokines / metabolism*
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Immunohistochemistry
  • Interleukin-4 / metabolism
  • Nasal Mucosa / metabolism
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rhinitis, Allergic, Perennial / metabolism*
  • Rhinitis, Allergic, Seasonal / metabolism*
  • Severity of Illness Index

Substances

  • Cytokines
  • RNA, Messenger
  • Interleukin-4
  • thymic stromal lymphopoietin