Abstract
The N-alkylated derivatives from nitrofurazone were synthesised and evaluated in vitro for their efficacy as antimicrobial agents against representative strains, including methicillin-resistant Staphylococcus aureus (MRSA). The derivative 2a demonstrated greater activity than the prototype and was comparable to currently used antimicrobial drugs.
MeSH terms
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Antifungal Agents* / chemical synthesis
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Antifungal Agents* / chemistry
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Antifungal Agents* / pharmacology
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Drug Design*
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Microbial Sensitivity Tests
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Molecular Structure
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Nitrofurazone* / chemical synthesis
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Nitrofurazone* / chemistry
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Nitrofurazone* / pharmacology
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Nitrofurazone