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Review
. 2008 Aug 14;14(30):4725-34.
doi: 10.3748/wjg.14.4725.

Hepatitis G virus

Vasiliy Ivanovich Reshetnyak  1 , Tatiana Igorevna Karlovich, Ljudmila Urievna Ilchenko
Affiliations
Review

Hepatitis G virus

Vasiliy Ivanovich Reshetnyak et al. World J Gastroenterol. .

Abstract

A number of new hepatitis viruses (G, TT, SEN) were discovered late in the past century. We review the data available in the literature and our own findings suggesting that the new hepatitis G virus (HGV), disclosed in the late 1990s, has been rather well studied. Analysis of many studies dealing with HGV mainly suggests the lymphotropicity of this virus. HGV or GBV-C has been ascertained to influence course and prognosis in the HIV-infected patient. Until now, the frequent presence of GBV-C in coinfections, hematological diseases, and biliary pathology gives no grounds to determine it as an "accidental tourist" that is of no significance. The similarity in properties of GBV-C and hepatitis C virus (HCV) offers the possibility of using HGV, and its induced experimental infection, as a model to study hepatitis C and to develop a hepatitis C vaccine.

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Figures

Figure 1
Figure 1
Affinity of HCV, GBV-C, GBV-A, and GBV-B (From Robertson BH, 2001)[5].
Figure 2
Figure 2
Schematic representation of GBV-C RNA structure, coded proteins, and their functions (from Kim JP, Frey KE)[14].
See this image and copyright information in PMC

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