Macrocyclic nonviral vectors: high cell transfection efficiency and low toxicity in a lower rim guanidinium calix[4]arene

Org Lett. 2008 Sep 18;10(18):3953-6. doi: 10.1021/ol801326d. Epub 2008 Aug 23.

Abstract

New multivalent cationic lipids, one of them showing high efficiency and low toxicity in cell transfection, have been obtained by attaching guanidinium groups at the lower rim of calix[4]arenes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calixarenes / chemical synthesis
  • Calixarenes / chemistry
  • Calixarenes / metabolism*
  • Calixarenes / toxicity*
  • Cell Line, Tumor
  • DNA / genetics
  • DNA / metabolism
  • Electrophoresis
  • Guanidine / chemistry*
  • Humans
  • Phenols / chemical synthesis
  • Phenols / chemistry
  • Phenols / metabolism*
  • Phenols / toxicity*
  • Phosphatidylethanolamines / metabolism
  • Transfection / instrumentation*
  • Transfection / methods*

Substances

  • 1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine
  • Phenols
  • Phosphatidylethanolamines
  • calix(4)arene
  • Calixarenes
  • DNA
  • Guanidine