RBM4: a multifunctional RNA-binding protein

Int J Biochem Cell Biol. 2009 Apr;41(4):740-3. doi: 10.1016/j.biocel.2008.05.027. Epub 2008 Aug 3.


RBM4, also known as Lark, was described initially as having a role in circadian rhythm control in Drosophila. In the last 5 years data have emerged from studies of mammalian cells. It is now clear that RBM4 is an RNA-binding protein involved in diverse cellular processes that include alternative splicing of pre-mRNA, translation, and RNA silencing. Its structure, similar to other RNA-binding proteins, contains two RNA recognition motifs and a CCHC-type zinc finger. Here we review current information about the function of RBM4 and its localization within the cell. We then speculate about its possible relationship to disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / physiology*


  • RBM4 protein, human
  • RNA-Binding Proteins