AMIN domains have a predicted role in localization of diverse periplasmic protein complexes

Bioinformatics. 2008 Nov 1;24(21):2423-6. doi: 10.1093/bioinformatics/btn449. Epub 2008 Aug 21.


We describe AMIN (Amidase N-terminal domain), a novel protein domain found specifically in bacterial periplasmic proteins. AMIN domains are widely distributed among peptidoglycan hydrolases and transporter protein families. Based on experimental data, contextual information and phyletic profiles, we suggest that AMIN domains mediate the targeting of periplasmic or extracellular proteins to specific regions of the bacterial envelope.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / analysis
  • Bacterial Proteins / chemistry*
  • Models, Genetic
  • Molecular Sequence Data
  • Periplasmic Proteins / analysis
  • Periplasmic Proteins / chemistry*
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Sequence Alignment


  • Bacterial Proteins
  • Periplasmic Proteins