Pathology of pulmonary aspergillomas

Indian J Pathol Microbiol. Jul-Sep 2008;51(3):342-5. doi: 10.4103/0377-4929.42507.


Aspergilloma refers to a fungal ball formed by saprophytic overgrowth of Aspergillus species and is seen secondary to cavitatory/cystic respiratory diseases. Paucity of clinical and pathological data of aspergilloma in India prompted us to analyze cases of aspergilloma over 15 years. The clinical features were recorded in all and correlated with detailed pathological examination. Aspergillomas were identified in 41 surgical excisions or at autopsy. There was male predominance; half the patients were in their fourth decade. Episodic hemoptysis was the commonest mode of presentation (85.4%). Forty aspergillomas were complex, occurring in cavitatory lesions (82.9%) or in bronchiectasis (14.6%). Simple aspergilloma was seen as an incidental finding in only one. Tuberculosis was the etiological factor in 31 patients, producing cavitatory or bronchiectatic lesions; other causes were chronic lung abscess and bronchiectasis (unrelated to tuberculosis). Surgical resections are endorsed in view of high risk of unpredictable, life-threatening hemoptysis.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Female
  • Hemoptysis / etiology
  • Humans
  • India
  • Male
  • Middle Aged
  • Mycetoma / pathology*
  • Mycetoma / physiopathology*
  • Mycetoma / surgery
  • Pulmonary Aspergillosis / pathology*
  • Pulmonary Aspergillosis / physiopathology*
  • Pulmonary Aspergillosis / surgery
  • Sex Factors