Hepatic tuberculosis mimicking Klatskin tumor: a diagnostic dilemma

Indian J Pathol Microbiol. 2008 Jul-Sep;51(3):382-5. doi: 10.4103/0377-4929.42517.

Abstract

Tubercular involvement of liver is rare and usually occurs in association with pulmonary or miliary tuberculosis, as diffuse involvement without recognizable pulmonary tuberculosis or rarely in a localized form, which presents as a tuberculoma or tubercular abscess. We report the case of a 22-year-old boy presenting with features of obstructive jaundice and a clinico-radiological picture highly suggestive of a perihilar cholangiocarcinoma (Klatskin tumor), but found to have tubercular involvement of porta hepatis. We review the literature on this unusual presentation, highlight the considerable diagnostic challenge such cases can pose, and also emphasize the need to consider tuberculosis in differential diagnosis of lesions involving the porta hepatis, particularly in areas endemic for the disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • DNA, Bacterial / genetics
  • Diagnosis, Differential
  • Humans
  • Klatskin Tumor / diagnosis*
  • Klatskin Tumor / diagnostic imaging
  • Klatskin Tumor / pathology
  • Klatskin Tumor / physiopathology
  • Liver / diagnostic imaging
  • Liver / pathology
  • Male
  • Mycobacterium / genetics
  • Mycobacterium / isolation & purification
  • Polymerase Chain Reaction / methods
  • Radiography
  • Tuberculosis, Hepatic / diagnosis*
  • Tuberculosis, Hepatic / diagnostic imaging
  • Tuberculosis, Hepatic / pathology
  • Tuberculosis, Hepatic / physiopathology
  • Young Adult

Substances

  • DNA, Bacterial