[Criteria for intoxication in the evaluation of severity of endotoxicosis, the efficiency of ozone therapy and traditional treatment in patients with diabetes mellitus complicated by pyonecrotic lesions of the lower extremities]

Klin Lab Diagn. 2008 Jun;(6):21-3.
[Article in Russian]


The severity of endotoxicosis was evaluated in 128 patients with type 2 diabetes mellitus complicated by pyonecrotic lesions of the lower extremities. There was evidence for a reduction in serum albumin concentration, which led to diminished detoxication capacities of the body. Concurrently, the effective albumin concentration and the binding capacity of both albumin and plasma became lower, which suggested higher blood toxicity. There was imbalance between the formation, accumulation and binding, utilization and elimination of toxic products, as confirmed by a rise in calculated intoxication criteria. Traditional therapy did not cause a significant reduction, which requires special detoxication therapy. Ozone therapy, an oxidative detoxication method substantially diminishes the severity of endogenous intoxication, as supported by an increase in the total concentration of albumin and its functional properties.

Publication types

  • English Abstract

MeSH terms

  • Aged
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetic Foot / etiology
  • Diabetic Foot / pathology
  • Diabetic Foot / therapy*
  • Endotoxemia / diagnosis
  • Endotoxemia / etiology
  • Endotoxemia / therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Necrosis
  • Ozone / therapeutic use*
  • Serum Albumin / analysis
  • Sodium Chloride
  • Suppuration
  • Ulcer / etiology
  • Ulcer / pathology
  • Ulcer / therapy


  • Serum Albumin
  • Sodium Chloride
  • Ozone