Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks

J Clin Periodontol. 2008 Sep;35(8 Suppl):398-409. doi: 10.1111/j.1600-051X.2008.01282.x.


Objectives: To review the evidence for the association between diabetes and periodontal and peri-implant conditions and the impact of periodontal therapy in subjects with diabetes.

Material and methods: A search of MEDLINE-PubMed was performed up to and including December 2007. The search was limited to clinical studies published in English. Publications on animal studies were excluded. The selection criteria included all levels of available evidence.

Results: Evidence on the association between diabetes and periodontitis supports the concept of increased severity but not extent of periodontitis in subjects with poorly controlled diabetes. Subjects with controlled diabetes do not show an increase in extent and severity of periodontitis. Periodontitis is associated with poor glycaemic control and diabetes-related complications. It is inconclusive that periodontal therapy with or without the use of antibiotics results in improvements of glycaemic control and of markers of systemic inflammation. Evidence is lacking to indicate that implant therapy in subjects with diabetes yields long-term outcomes comparable with those of non-diabetic subjects.

Conclusions: Poorly controlled diabetes may be considered a risk factor for increased severity of periodontitis. The effects of periodontal therapy on glycaemic control and systemic inflammation is not proven beyond doubt and need to be confirmed in large-scale randomized-controlled clinical trials.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Blood Glucose / analysis
  • Dental Implants*
  • Dental Scaling
  • Diabetes Complications / blood
  • Diabetes Complications / physiopathology*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 2 / complications
  • Humans
  • Inflammation Mediators / blood
  • Periodontal Diseases / blood
  • Periodontal Diseases / complications*
  • Periodontal Diseases / therapy
  • Periodontitis / blood
  • Periodontitis / complications
  • Periodontitis / therapy
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • Root Planing


  • Anti-Bacterial Agents
  • Blood Glucose
  • Dental Implants
  • Inflammation Mediators